ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RAC1

Full Name:

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

Alias:

MGC111543|MIG5|TC-25|p21-Rac1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7p22

Physical Location:

6380650-6410122 on NC_000007.12

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 19353 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

RAC1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D7S517

4464441

Region:		2464441-6464441
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0042470	melanosome	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (7744773\|10648409\|14737186)
GO:0030742	GTP-dependent protein binding	Molecular Function	IPI (10954424)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	TAS (9312003)
GO:0035025	positive regulation of Rho protein signal transduction	Biological Process	TAS (9312003)
GO:0031529	ruffle organization and biogenesis	Biological Process	TAS (9312003)
GO:0030041	actin filament polymerization	Biological Process	TAS (9312003)
GO:0030032	lamellipodium biogenesis	Biological Process	IMP (9312003)
GO:0009653	anatomical structure morphogenesis	Biological Process	TAS (9572733)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	TAS (9572733)
GO:0006954	inflammatory response	Biological Process	TAS (9572733)
GO:0006928	cell motility	Biological Process	TAS (9572733)
GO:0048261	negative regulation of receptor-mediated endocytosis	Biological Process	TAS (9312003)