ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rasal1

Full Name:

RAS protein activator like 1 (GAP1 like)

Alias:

MRASAL

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 F

Physical Location:

121098830-121129601 on NC_000071.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8437 Symbol (Name): RASAL1 (RAS protein activator like 1 (GAP1 like))

Ortholog Status:

The human GeneID 8437 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rasal1
Original ID2:		AF086714

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013832.3	NP_038860.2	NC_000071.5 range: 121098830..121129601

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005096	GTPase activator activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process	IEA