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Gene Information
Gene ID:1956
Symbol:EGFR
Full Name:epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Alias:ERBB|ERBB1|HER1|PIG61|mENA
Organism:Homo sapiens (Human)
Chromosome:7
Genetic Location:7p12
Physical Location:55054218-55242524 on NC_000007.12
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:EGFR
Original ID2:H02836
Dataset Information
Name:11093800
Method:Microarray
Tissue:SH-SY5Y neuroblastoma cells
Phenotype:Ethanol response
Publication:Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.
Gene Information
Original ID1:EGFR
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005228.3NP_005219.2NC_000007.12 range: 55054218..55242524
NM_201282.1NP_958439.1NC_000007.12 range: 55054218..55242524
NM_201283.1NP_958440.1NC_000007.12 range: 55054218..55242524
NM_201284.1NP_958441.1NC_000007.12 range: 55054218..55242524
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIDA (15465819)
GO:0005768endosomeCellular ComponentIDA (14702346)
GO:0005737cytoplasmCellular ComponentIDA (12435727)
GO:0005634nucleusCellular ComponentIDA (12828935)
GO:0005615extracellular spaceCellular ComponentNAS (9103388)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentEXP (8493579|8639530|8845374|9356464|9544989|10567358|10648629|10734310|10913131|11823423|11894095|122181)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016323basolateral plasma membraneCellular ComponentIDA (12646923)
GO:0030122AP-2 adaptor complexCellular ComponentTAS (14702346)
GO:0046982protein heterodimerization activityMolecular FunctionIDA (10572067)
GO:0016740transferase activityMolecular FunctionIEA
GO:0030235nitric-oxide synthase regulator activityMolecular FunctionIDA (12828935)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0051015actin filament bindingMolecular FunctionIDA (14702346)
GO:0003690double-stranded DNA bindingMolecular FunctionNAS (6325948)
GO:0004710MAP/ERK kinase kinase activityMolecular FunctionNAS (15542601)
GO:0004888transmembrane receptor activityMolecular FunctionIDA (7736574)
GO:0005006epidermal growth factor receptor activityMolecular FunctionIDA (12435727)
GO:0005006epidermal growth factor receptor activityMolecular FunctionNAS (2790960|6325948)
GO:0042802identical protein bindingMolecular FunctionIPI (16777603)
GO:0045786negative regulation of cell cycleBiological ProcessIEA
GO:0045429positive regulation of nitric oxide biosynthetic processBiological ProcessIDA (12828935)
GO:0050679positive regulation of epithelial cell proliferationBiological ProcessIDA (10572067)
GO:0050730regulation of peptidyl-tyrosine phosphorylationBiological ProcessIMP (12435727)
GO:0050999regulation of nitric-oxide synthase activityBiological ProcessIDA (12828935)
GO:0043406positive regulation of MAP kinase activityBiological ProcessIDA (10572067)
GO:0043006calcium-dependent phospholipase A2 activationBiological ProcessTAS (12435727)
GO:0042327positive regulation of phosphorylationBiological ProcessIDA (15082764)
GO:0001503ossificationBiological ProcessNAS (12925580)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0006950response to stressBiological ProcessNAS (12828935)
GO:0007166cell surface receptor linked signal transductionBiological ProcessIDA (7736574)
GO:0007173epidermal growth factor receptor signaling pathwayBiological ProcessIDA (12435727)
GO:0007202activation of phospholipase C activityBiological ProcessTAS (12435727)
GO:0016337cell-cell adhesionBiological ProcessIMP (12435727)
GO:0030335positive regulation of cell migrationBiological ProcessIMP (12435727)
GO:0051205protein insertion into membraneBiological ProcessTAS (12435727)
Other Database Cross Links
NCBI Entrez Gene:1956
HGNC:3236
Ensembl:ENSG00000146648
MIM:131550
HPRD:00579
HuGE Navigator:1956
dbSNP:EGFR
GeneCard:EGFR
AceView:EGFR