ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

19645

Symbol:

Rb1

Full Name:

retinoblastoma 1

Alias:

Rb|Rb-1|pRb

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

14 D3|14 41.0 cM

Physical Location:

73595308-73725546 on NC_000080.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5925 Symbol (Name): RB1 (retinoblastoma 1 (including osteosarcoma))

Ortholog Status:

The human GeneID 5925 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws5/Alcw7	Chronic Alcohol Withdrawal	14		24-48 (cM)	4.2	6.00E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009029.2	NP_033055.2	NC_000080.5 range: 73595308..73725546, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (10082561\|15616565\|15701640\|16513252)
GO:0005667	transcription factor complex	Cellular Component	IDA (10082561)
GO:0005819	spindle	Cellular Component	IDA (15509711)
GO:0016564	transcription repressor activity	Molecular Function	IDA (11331592)
GO:0008134	transcription factor binding	Molecular Function	IPI (9178770)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10082561\|12200151\|15367658\|15701640\|15870077\|15983387)
GO:0045786	negative regulation of cell cycle	Biological Process	IMP (12853964)
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IMP (15831459)
GO:0045651	positive regulation of macrophage differentiation	Biological Process	IGI (15616565)
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA (11331592)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (15701640)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15701640)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IMP (15701640)
GO:0051146	striated muscle cell differentiation	Biological Process	IGI (15542848)
GO:0051301	cell division	Biological Process	IMP (15843406)
GO:0043353	enucleate erythrocyte differentiation	Biological Process	IGI (15616565)
GO:0016568	chromatin modification	Biological Process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (12200151)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15870077)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0007050	cell cycle arrest	Biological Process	IMP (15831459)
GO:0008285	negative regulation of cell proliferation	Biological Process	IGI (11246230)
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (15843406)
GO:0051726	regulation of cell cycle	Biological Process	IMP (15898111)