ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rbp4

Full Name:

retinol binding protein 4, plasma

Alias:

Rbp-4

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

19 D1|19 38.0 cM

Physical Location:

38191118-38199737 on NC_000085.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5950 Symbol (Name): RBP4 (retinol binding protein 4, plasma)

Ortholog Status:

The human GeneID 5950 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rbp4
Original ID2:		U63146

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Calw2/Alcdp2	Chronic Alcohol Withdrawal	19	47	36.5-ter (cM)	5.3	6.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011255.2	NP_035385.1	NC_000085.5 range: 38191118..38199737, complement

Gene Ontology (GO) Annotation