ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rpo1-1

Full Name:

RNA polymerase 1-1

Alias:

40kDa|AA409007|AA959927|AL024089|MGC161175|RPA40

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 C

Physical Location:

46380868-46384993 on NC_000083.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9533 Symbol (Name): POLR1C (polymerase (RNA) I polypeptide C, 30kDa)

Ortholog Status:

The human GeneID 9533 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rpo1-1
Original ID2:		U11248

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009085.2	NP_033111.2	NC_000083.5 range: 46380868..46384993, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003899	DNA-directed RNA polymerase activity	Molecular Function	IEA
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA