ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sema6b

Full Name:

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

Alias:

MGC143995|MGC143996|Sema|Seman|VIb|semaZ

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 D

Physical Location:

56262507-56272287 on NC_000083.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10501 Symbol (Name): SEMA6B (sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B)

Ortholog Status:

The human GeneID 10501 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Sema6b
Original ID2:		AF036585

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013662.1	NP_038690.1	NC_000083.5 range: 56262507..56272287, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (16141072)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007399	nervous system development	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA