ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Frzb

Full Name:

frizzled-related protein

Alias:

Frp|Sfrp3|frezzled|fritz|frzb-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 C3|2 49.75 cM

Physical Location:

80252126-80287552 on NC_000068.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2487 Symbol (Name): FRZB (frizzled-related protein)

Ortholog Status:

The human GeneID 2487 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Frzb
Original ID2:		U68058

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Etact1	Alcohol Stimulated Activity	2	51	41-61 (cM)	3.9	2.20E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011356.4	NP_035486.1	NC_000068.6 range: 80252126..80287552, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	NAS (9178261)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005515	protein binding	Molecular Function	IEA
GO:0017147	Wnt-protein binding	Molecular Function	IDA (9178261)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0016055	Wnt receptor signaling pathway	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0030178	negative regulation of Wnt receptor signaling pathway	Biological Process	IDA (9178261)