ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sgk1

Full Name:

serum/glucocorticoid regulated kinase 1

Alias:

Sgk

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 A3

Physical Location:

21714501-21719697 on NC_000076.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6446 Symbol (Name): SGK1 (serum/glucocorticoid regulated kinase 1)

Ortholog Status:

The human GeneID 6446 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AW046181
Fold Change:		2.0, 1.9, 3.5, 3.5
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Information

Original ID1:		Sgk
Original ID2:		AW046181

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011361.1	NP_035491.1	NC_000076.5 range: 21714501..21719697

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15665527)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IDA (15383658)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (15383658)
GO:0006915	apoptosis	Biological Process	IEA
GO:0006974	response to DNA damage stimulus	Biological Process	IDA (15383658)