ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

St8sia3

Full Name:

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

Alias:

AI847333|ST8SiaIII|Siat8c

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 E1

Physical Location:

64425041-64435797 on NC_000084.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 51046 Symbol (Name): ST8SIA3 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3)

Ortholog Status:

The human GeneID 51046 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Siat8c
Original ID2:		X80502

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009182.2	NP_033208.2	NC_000084.5 range: 64425041..64435797

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (16141072)
GO:0030173	integral to Golgi membrane	Cellular Component	IEA
GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	Molecular Function	IDA (7782326)
GO:0008373	sialyltransferase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function	IEA
GO:0006486	protein amino acid glycosylation	Biological Process	IEA