ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

EPHX2

Full Name:

epoxide hydrolase 2, cytoplasmic

Alias:

CEH|SEH

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8p21-p12

Physical Location:

27404561-27458402 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 13850 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.212088
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Information

Original ID1:

EPHX2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001979.4	NP_001970.2	NC_000008.9 range: 27404561..27458402

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	NAS (10862610)
GO:0005625	soluble fraction	Cellular Component	NAS (10862610)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005777	peroxisome	Cellular Component	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	NAS (10862610)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004301	epoxide hydrolase activity	Molecular Function	IDA (10862610)
GO:0019439	aromatic compound catabolic process	Biological Process	IEA
GO:0017144	drug metabolic process	Biological Process	NAS (10862610)
GO:0009636	response to toxin	Biological Process	NAS (10862610)
GO:0008217	regulation of blood pressure	Biological Process	NAS (10862610)
GO:0008152	metabolic process	Biological Process	IEA
GO:0006954	inflammatory response	Biological Process	NAS (10862610)
GO:0006874	cellular calcium ion homeostasis	Biological Process	NAS (10862610)
GO:0006805	xenobiotic metabolic process	Biological Process	NAS (10862610)
GO:0006800	oxygen and reactive oxygen species metabolic process	Biological Process	NAS (10862610)
GO:0045909	positive regulation of vasodilation	Biological Process	NAS (10862610)