ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slpi

Full Name:

secretory leukocyte peptidase inhibitor

Organism:

Mus musculus (Mouse)

Chromosome:

Physical Location:

164179805-164198445 on NC_000068.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6590 Symbol (Name): SLPI (secretory leukocyte peptidase inhibitor)

Ortholog Status:

The human GeneID 6590 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Slpi
Original ID2:		AV087239

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011414.2	NP_035544.1	NC_000068.6 range: 164179805..164198445, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0004866	endopeptidase inhibitor activity	Molecular Function	IEA
GO:0004867	serine-type endopeptidase inhibitor activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0030414	protease inhibitor activity	Molecular Function	IEA