ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sstr2

Full Name:

somatostatin receptor 2

Alias:

SSTR-2|Smstr-2|Smstr2|sst2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 E2|11 69.0 cM

Physical Location:

113485570-113486949 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6752 Symbol (Name): SSTR2 (somatostatin receptor 2)

Ortholog Status:

The human GeneID 6752 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Sstr2
Original ID2:		AF008914

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IDA (9166719)
GO:0005624	membrane fraction	Cellular Component	IDA (7929134)
GO:0004994	somatostatin receptor activity	Molecular Function	IDA (1346068\|7929134)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0004994	somatostatin receptor activity	Molecular Function	IMP (7929134)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	Biological Process	IDA (9166719)
GO:0007218	neuropeptide signaling pathway	Biological Process	IDA (9166719)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IMP (7929134)