ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sox10

Full Name:

SRY-box containing gene 10

Alias:

Dom|Sox21

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 E1|15 46.6 cM

Physical Location:

78985342-78996156 on NC_000081.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6663 Symbol (Name): SOX10 (SRY (sex determining region Y)-box 10)

Ortholog Status:

The human GeneID 6663 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Sox10
Original ID2:		AF047389

Gene Information

Original ID1:		Sox10
Original ID2:		AW125812

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC
Aaq1/Etacc	Alcohol Acceptance	15	30	15-48 (cM)	3.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_128139.6	XP_128139.5	NC_000081.5 range: 78985342..78996156, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IDA (15102707)
GO:0003682	chromatin binding	Molecular Function	IDA (15729346)
GO:0003705	RNA polymerase II transcription factor activity, enhancer binding	Molecular Function	IDA (15729346)
GO:0001701	in utero embryonic development	Biological Process	IGI (16790476)
GO:0048469	cell maturation	Biological Process	IGI (15102707)
GO:0048469	cell maturation	Biological Process	IMP (15102707)
GO:0048484	enteric nervous system development	Biological Process	IMP (16790476)
GO:0048589	developmental growth	Biological Process	IMP (16790476)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15729346)
GO:0030318	melanocyte differentiation	Biological Process	IMP (16790476)
GO:0030154	cell differentiation	Biological Process	IMP (11799060)
GO:0007422	peripheral nervous system development	Biological Process	IGI (16790476)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0048709	oligodendrocyte differentiation	Biological Process	IMP (16790476)