ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Spin1

Full Name:

spindlin 1

Alias:

AA553322|AA673430|MGC27756|Spin

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

13 A5|13 31.0 cM

Physical Location:

51196266-51247914 on NC_000079.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10927 Symbol (Name): SPIN1 (spindlin 1)

Ortholog Status:

The human GeneID 10927 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Spin
Original ID2:		AW124681

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005819	spindle	Cellular Component	IDA (9053325\|9590541)
GO:0003674	molecular_function	Molecular Function	ND
GO:0007049	cell cycle	Biological Process	IEA
GO:0007143	female meiosis	Biological Process	IC (9053325\|9590541)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007276	gamete generation	Biological Process	IEA