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Gene Information
Gene ID:20756
Full Name:small proline-rich protein 2B
Organism:Mus musculus (Mouse)
Genetic Location:3 F1|3 45.2 cM
Physical Location:92120626-92122006 on NC_000069.5
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Sprr2b
Original ID2:AJ005560
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011469.3NP_035599.2NC_000069.5 range: 92120626..92122006
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0001533cornified envelopeCellular ComponentNAS (8325635)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005198structural molecule activityMolecular FunctionIEA
GO:0008544epidermis developmentBiological ProcessNAS (8325635)
GO:0030216keratinocyte differentiationBiological ProcessNAS (8325635)
GO:0031424keratinizationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:20756