ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Stx1a

Full Name:

syntaxin 1A (brain)

Alias:

HPC-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 G2

Physical Location:

135499441-135526968 on NC_000071.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6804 Symbol (Name): STX1A (syntaxin 1A (brain))

Ortholog Status:

The human GeneID 6804 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Stx1a
Original ID2:		D45208

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016801.3	NP_058081.2	NC_000071.5 range: 135499441..135526968

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030672	synaptic vesicle membrane	Cellular Component	IDA (12805290)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0005886	plasma membrane	Cellular Component	IDA (10468580)
GO:0005886	plasma membrane	Cellular Component	TAS (12145198)
GO:0016020	membrane	Cellular Component	IEA
GO:0019855	calcium channel inhibitor activity	Molecular Function	IMP (10468580)
GO:0000149	SNARE binding	Molecular Function	IDA (12145198)
GO:0005515	protein binding	Molecular Function	IPI (10468580\|12832401\|17500595)
GO:0005484	SNAP receptor activity	Molecular Function	IEA
GO:0006836	neurotransmitter transport	Biological Process	IEA
GO:0007268	synaptic transmission	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0016192	vesicle-mediated transport	Biological Process	IEA
GO:0017156	calcium ion-dependent exocytosis	Biological Process	IMP (10468580)
GO:0006886	intracellular protein transport	Biological Process	IEA