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Gene Information
Gene ID:20977
Symbol:Syp
Full Name:synaptophysin
Alias:A230093K24Rik|AI848995|Syn|p38
Organism:Mus musculus (Mouse)
Chromosome:X
Genetic Location:X A-D|X 1.5 cM
Physical Location:7215836-7230376 on NC_000086.6
Gene Type:protein-coding
Human Ortholog:GeneID: 6855    Symbol (Name): SYP (synaptophysin)
Ortholog Status:The human GeneID 6855 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Syp
Fold Change:0.72
Note:Significantly regulated by ethanol in cortical neurons
Gene Information
Original ID1:Syp
Fold Change:0.64
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009305.2NP_033331.2NC_000086.6 range: 7215836..7230376
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045202synapseCellular ComponentIDA (10995443|12533614|14622577|17823315)
GO:0042734presynaptic membraneCellular ComponentIDA (15328414)
GO:0031410cytoplasmic vesicleCellular ComponentIEA
GO:0030672synaptic vesicle membraneCellular ComponentIDA (12805290|15071120)
GO:0030285integral to synaptic vesicle membraneCellular ComponentTAS (12271488)
GO:0030054cell junctionCellular ComponentIEA
GO:0019717synaptosomeCellular ComponentIDA (12368914)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0008021synaptic vesicleCellular ComponentISS (12928441)
GO:0008021synaptic vesicleCellular ComponentIDA (11879655|12202822)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005215transporter activityMolecular FunctionIEA
GO:0007268synaptic transmissionBiological ProcessTAS (12271488)
GO:0006897endocytosisBiological ProcessTAS (12271488)
GO:0006810transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:20977
MGI:
Ensembl:ENSMUSG00000031144
dbSNP:Syp
AceView:Syp