ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tac1

Full Name:

tachykinin 1

Alias:

4930528L02Rik|MGC151458|NK-1|NK1|Nkna|PPT-A|SP

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 A1|6 5.0 cM

Physical Location:

7505070-7512972 on NC_000072.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6863 Symbol (Name): TAC1 (tachykinin, precursor 1)

Ortholog Status:

The human GeneID 6863 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Tac1
Original ID2:		D17584

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009311.2	NP_033337.1	NC_000072.5 range: 7505070..7512972

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IDA (9537322)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0043025	cell soma	Cellular Component	IDA (9853118\|12888222)
GO:0030424	axon	Cellular Component	IDA (1317267\|7521790)
GO:0019233	sensory perception of pain	Biological Process	IMP (9537322)
GO:0007268	synaptic transmission	Biological Process	IEA
GO:0007218	neuropeptide signaling pathway	Biological Process	IEA
GO:0007217	tachykinin signaling pathway	Biological Process	IEA
GO:0006954	inflammatory response	Biological Process	IDA (15159534)
GO:0048265	response to pain	Biological Process	IMP (11805341)