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Gene Information
Gene ID:21333
Full Name:tachykinin 1
Organism:Mus musculus (Mouse)
Genetic Location:6 A1|6 5.0 cM
Physical Location:7505070-7512972 on NC_000072.5
Gene Type:protein-coding
Human Ortholog:GeneID: 6863    Symbol (Name): TAC1 (tachykinin, precursor 1)
Ortholog Status:The human GeneID 6863 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Tac1
Original ID2:D17584
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009311.2NP_033337.1NC_000072.5 range: 7505070..7512972
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIDA (9537322)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0043025cell somaCellular ComponentIDA (9853118|12888222)
GO:0030424axonCellular ComponentIDA (1317267|7521790)
GO:0019233sensory perception of painBiological ProcessIMP (9537322)
GO:0007268synaptic transmissionBiological ProcessIEA
GO:0007218neuropeptide signaling pathwayBiological ProcessIEA
GO:0007217tachykinin signaling pathwayBiological ProcessIEA
GO:0006954inflammatory responseBiological ProcessIDA (15159534)
GO:0048265response to painBiological ProcessIMP (11805341)
Other Database Cross Links
NCBI Entrez Gene:21333