ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tbl1x

Full Name:

transducin (beta)-like 1 X-linked

Alias:

5330429M20|Tbl1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

X B-C|X 30.9 cM

Physical Location:

74756565-74905603 on NC_000086.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6907 Symbol (Name): TBL1X (transducin (beta)-like 1X-linked)

Ortholog Status:

The human GeneID 6907 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Tbl1x
Original ID2:		AV230631

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Information

Dataset Information

Name:		16783646
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Alcohol preference, acute functional tolerance
Publication:		Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:		Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_020601.2	NP_065626.1	NC_000086.6 range: 74756565..74905603

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005667	transcription factor complex	Cellular Component	IDA (15728386)
GO:0003682	chromatin binding	Molecular Function	IDA (15728386)
GO:0005515	protein binding	Molecular Function	IPI (15728386)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15728386)
GO:0006512	ubiquitin cycle	Biological Process	IEA