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Gene Information
Gene ID:21372
Full Name:transducin (beta)-like 1 X-linked
Organism:Mus musculus (Mouse)
Genetic Location:X B-C|X 30.9 cM
Physical Location:74756565-74905603 on NC_000086.6
Gene Type:protein-coding
Human Ortholog:GeneID: 6907    Symbol (Name): TBL1X (transducin (beta)-like 1X-linked)
Ortholog Status:The human GeneID 6907 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Tbl1x
Original ID2:AV230631
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Information
Original ID1:Tbl1x
Fold Change:4.21
P Value:0.032
Note:acute functional tolerance
Dataset Information
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Alcohol preference, acute functional tolerance
Publication:Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_020601.2NP_065626.1NC_000086.6 range: 74756565..74905603
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005667transcription factor complexCellular ComponentIDA (15728386)
GO:0003682chromatin bindingMolecular FunctionIDA (15728386)
GO:0005515protein bindingMolecular FunctionIPI (15728386)
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessIGI (15728386)
GO:0006512ubiquitin cycleBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:21372