ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tbr1

Full Name:

T-box brain gene 1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 C1.3|2 32.0 cM

Physical Location:

61642509-61652170 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10716 Symbol (Name): TBR1 (T-box, brain, 1)

Ortholog Status:

The human GeneID 10716 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Tbr1
Original ID2:		U49251

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcp1	Alcohol Preference Drinking	2	28	19-35 (cM)	5.3		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009322.3	NP_033348.2	NC_000068.6 range: 61642509..61652170

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (14999075\|16202707)
GO:0003677	DNA binding	Molecular Function	IDA (15584924)
GO:0003700	transcription factor activity	Molecular Function	IDA (14999075)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0007411	axon guidance	Biological Process	IMP (11967891)
GO:0030902	hindbrain development	Biological Process	IMP (16540585)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (15584924)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15584924)