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Gene Information
Gene ID:216134
Full Name:pyridoxal (pyridoxine, vitamin B6) kinase
Organism:Mus musculus (Mouse)
Genetic Location:10 C1|10 42.1 cM
Physical Location:77901714-77927719 on NC_000076.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8566    Symbol (Name): PDXK (pyridoxal (pyridoxine, vitamin B6) kinase)
Ortholog Status:The human GeneID 8566 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pdxk
Original ID2:AI450876
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_172134.2NP_742146.1NC_000076.5 range: 77901714..77927719, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0008478pyridoxal kinase activityMolecular FunctionRCA (12466851)
GO:0016301kinase activityMolecular FunctionRCA (12466851)
GO:0016740transferase activityMolecular FunctionRCA (12466851)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0008615pyridoxine biosynthetic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:216134