ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdxk

Full Name:

pyridoxal (pyridoxine, vitamin B6) kinase

Alias:

2310036D04Rik|AA119688|C77999

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 C1|10 42.1 cM

Physical Location:

77901714-77927719 on NC_000076.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8566 Symbol (Name): PDXK (pyridoxal (pyridoxine, vitamin B6) kinase)

Ortholog Status:

The human GeneID 8566 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pdxk
Original ID2:		AI450876

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_172134.2	NP_742146.1	NC_000076.5 range: 77901714..77927719, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008478	pyridoxal kinase activity	Molecular Function	RCA (12466851)
GO:0016301	kinase activity	Molecular Function	RCA (12466851)
GO:0016740	transferase activity	Molecular Function	RCA (12466851)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008615	pyridoxine biosynthetic process	Biological Process	IEA