ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ift88

Full Name:

intraflagellar transport 88 homolog (Chlamydomonas)

Alias:

AW552028|Tg737|Tg737Rpw|TgN737Rpw|Ttc10|flexo|fxo|orpk|polaris

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

14 C3|14 21.0 cM

Physical Location:

58042962-58136772 on NC_000080.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8100 Symbol (Name): IFT88 (intraflagellar transport 88 homolog (Chlamydomonas))

Ortholog Status:

The human GeneID 8100 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Tg737Rpw
Original ID2:		AI451701

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009376.1	NP_033402.1	NC_000080.5 range: 58042962..58136772

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005930	axoneme	Cellular Component	IDA (11251073)
GO:0005932	basal body	Cellular Component	IDA (11251073\|11854326)
GO:0019861	flagellum	Cellular Component	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0045862	positive regulation of proteolysis	Biological Process	IMP (15930098)
GO:0042733	embryonic digit morphogenesis	Biological Process	IMP (12701101\|15755804\|15930098)
GO:0042733	embryonic digit morphogenesis	Biological Process	IGI (15930098)
GO:0042487	regulation of odontogenesis of dentine-containing teeth	Biological Process	IMP (12701101)
GO:0009953	dorsal/ventral pattern formation	Biological Process	IMP (15755804\|15930098)
GO:0009952	anterior/posterior pattern formation	Biological Process	IMP (12701101\|15930098)
GO:0009887	organ morphogenesis	Biological Process	IMP (15226261)
GO:0007368	determination of left/right symmetry	Biological Process	IMP (10804177\|15755804)
GO:0007224	smoothened signaling pathway	Biological Process	IMP (15930098)
GO:0007224	smoothened signaling pathway	Biological Process	IGI (15930098)
GO:0048598	embryonic morphogenesis	Biological Process	IGI (15930098)