ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

21823

Symbol:

Full Name:

tyrosine hydroxylase

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

7 F5|7 69.2 cM

Physical Location:

150078680-150085870 on NC_000073.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7054 Symbol (Name): TH (tyrosine hydroxylase)

Ortholog Status:

The human GeneID 7054 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Th
Original ID2:		M69200

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009377.1	NP_033403.1	NC_000073.5 range: 150078680..150085870, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (10707987)
GO:0043204	perikaryon	Cellular Component	IDA (10350535)
GO:0005634	nucleus	Cellular Component	IDA (15643613)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0004511	tyrosine 3-monooxygenase activity	Molecular Function	TAS (7592982)
GO:0004497	monooxygenase activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0009072	aromatic amino acid family metabolic process	Biological Process	IEA
GO:0009887	organ morphogenesis	Biological Process	IMP (7715703)
GO:0042136	neurotransmitter biosynthetic process	Biological Process	IEA
GO:0042423	catecholamine biosynthetic process	Biological Process	IEA
GO:0042755	eating behavior	Biological Process	IGI (10802666\|12538862)
GO:0042755	eating behavior	Biological Process	IMP (11430814\|15374756)
GO:0008016	regulation of heart contraction	Biological Process	IMP (7592982\|7715703)
GO:0007626	locomotory behavior	Biological Process	IMP (11430814\|14684249)
GO:0007626	locomotory behavior	Biological Process	IGI (12538862)
GO:0006585	dopamine biosynthetic process from tyrosine	Biological Process	IDA (9520487)
GO:0006585	dopamine biosynthetic process from tyrosine	Biological Process	IMP (7592982\|7715703)
GO:0006585	dopamine biosynthetic process from tyrosine	Biological Process	TAS (10212311)
GO:0007268	synaptic transmission	Biological Process	IEA
GO:0007507	heart development	Biological Process	IMP (7715703\|10212311)
GO:0007612	learning	Biological Process	IMP (14684249)
GO:0007613	memory	Biological Process	IMP (14684249)
GO:0007617	mating behavior	Biological Process	IMP (9829800)
GO:0001963	synaptic transmission, dopaminergic	Biological Process	IMP (12604788\|15317940)