ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tie1

Full Name:

tyrosine kinase receptor 1

Alias:

D430008P04Rik|TIE|tie-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 D2.1|4 50.0 cM

Physical Location:

118143795-118162453 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7075 Symbol (Name): TIE1 (tyrosine kinase with immunoglobulin-like and EGF-like domains 1)

Ortholog Status:

The human GeneID 7075 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws2	Chronic Alcohol Withdrawal	4		33-51 (cM)	2.3	0.005	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011587.2	NP_035717.2	NC_000070.5 range: 118143795..118162453, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	ISM (8415706)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0016525	negative regulation of angiogenesis	Biological Process	IMP (9683559)
GO:0030336	negative regulation of cell migration	Biological Process	IMP (9683559)
GO:0045026	plasma membrane fusion	Biological Process	IMP (9683559)