ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tlr4

Full Name:

toll-like receptor 4

Alias:

Lps|Ly87|Ran/M1|Rasl2-8

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 C1|4 33.0 cM

Physical Location:

66488844-66503830 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7099 Symbol (Name): TLR4 (toll-like receptor 4)

Ortholog Status:

The human GeneID 7099 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws2	Chronic Alcohol Withdrawal	4		33-51 (cM)	2.3	0.005	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021297.2	NP_067272.1	NC_000070.5 range: 66488844..66503830

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031224	intrinsic to membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17803912)
GO:0004888	transmembrane receptor activity	Molecular Function	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0046330	positive regulation of JNK cascade	Biological Process	IDA (16260493)
GO:0045576	mast cell activation	Biological Process	NAS (11490012\|11739561)
GO:0045410	positive regulation of interleukin-6 biosynthetic process	Biological Process	NAS (11490012)
GO:0045368	positive regulation of interleukin-13 biosynthetic process	Biological Process	NAS (11490012)
GO:0045362	positive regulation of interleukin-1 biosynthetic process	Biological Process	NAS (11490012)
GO:0045087	innate immune response	Biological Process	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IDA (16260493)
GO:0042116	macrophage activation	Biological Process	ISS (10835634)
GO:0006954	inflammatory response	Biological Process	IEA
GO:0009617	response to bacterium	Biological Process	IMP (11294571)
GO:0007250	activation of NF-kappaB-inducing kinase activity	Biological Process	NAS (11490012)
GO:0007165	signal transduction	Biological Process	IEA
GO:0046330	positive regulation of JNK cascade	Biological Process	IGI (16260493)