ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

7099

Symbol:

TLR4

Full Name:

toll-like receptor 4

Alias:

ARMD10|CD284|TOLL|hToll

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9q32-q33

Physical Location:

119506430-119519588 on NC_000009.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 21898 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

TLR4

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_138554.2	NP_612564.1	NC_000009.10 range: 119506430..119519588

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA (15027902)
GO:0046696	lipopolysaccharide receptor complex	Cellular Component	NAS (11970998)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	IDA (15027902)
GO:0005886	plasma membrane	Cellular Component	EXP (12447442\|14556004\|14625308\|16024789)
GO:0005515	protein binding	Molecular Function	IPI (11544529)
GO:0004888	transmembrane receptor activity	Molecular Function	IEA
GO:0001530	lipopolysaccharide binding	Molecular Function	NAS (10835634)
GO:0004888	transmembrane receptor activity	Molecular Function	NAS (11970998)
GO:0005515	protein binding	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	TAS (9435236\|10426995)
GO:0045671	negative regulation of osteoclast differentiation	Biological Process	NAS (12133979)
GO:0045416	positive regulation of interleukin-8 biosynthetic process	Biological Process	IDA (17951129)
GO:0045087	innate immune response	Biological Process	IEA
GO:0045084	positive regulation of interleukin-12 biosynthetic process	Biological Process	NAS (11970998)
GO:0045084	positive regulation of interleukin-12 biosynthetic process	Biological Process	IDA (15027902)
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	Biological Process	IDA (17951129)
GO:0006954	inflammatory response	Biological Process	IEA
GO:0042088	T-helper 1 type immune response	Biological Process	NAS (11970998)
GO:0016046	detection of fungus	Biological Process	NAS (11254600)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007249	I-kappaB kinase/NF-kappaB cascade	Biological Process	EXP (15276183)
GO:0042116	macrophage activation	Biological Process	IMP (10835634)