Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:21926
Symbol:Tnf
Full Name:tumor necrosis factor
Alias:DIF|MGC151434|TNF-alpha|TNFSF2|TNFalpha|Tnfa|Tnfsf1a
Organism:Mus musculus (Mouse)
Chromosome:17
Genetic Location:17 B1|17 19.06 cM
Physical Location:35336334-35338940 on NC_000083.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7124    Symbol (Name): TNF (tumor necrosis factor (TNF superfamily, member 2))
Ortholog Status:The human GeneID 7124 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Tnf
Fold Change:0.58
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013693.2NP_038721.1NC_000083.5 range: 35336334..35338940, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005887integral to plasma membraneCellular ComponentTAS (8879212)
GO:0055037recycling endosomeCellular ComponentIDA (16282525)
GO:0009897external side of plasma membraneCellular ComponentIDA (16282525)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIDA (15155767)
GO:0005615extracellular spaceCellular ComponentIDA (1577194|10545106|10899905|11728336|12855817|12872135|14764707|15220916|16275384)
GO:0005576extracellular regionCellular ComponentIEA
GO:0030141secretory granuleCellular ComponentTAS (8879212)
GO:0001891phagocytic cupCellular ComponentIDA (16282525)
GO:0005515protein bindingMolecular FunctionIGI (16702408)
GO:0005125cytokine activityMolecular FunctionIDA (11588035)
GO:0005164tumor necrosis factor receptor bindingMolecular FunctionIDA (11588035)
GO:0005164tumor necrosis factor receptor bindingMolecular FunctionTAS (8171322|8387893|8395024|9223320|9256477|9368616|9565643)
GO:0042742defense response to bacteriumBiological ProcessIDA (10899905)
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeBiological ProcessIGI (16260493)
GO:0045123cellular extravasationBiological ProcessIDA (10528208)
GO:0045670regulation of osteoclast differentiationBiological ProcessIDA (12490655)
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeBiological ProcessIDA (12867038|16260493)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (9305915)
GO:0045994positive regulation of translational initiation by ironBiological ProcessIDA (11588035)
GO:0045941positive regulation of transcriptionBiological ProcessIDA (12761567)
GO:0051798positive regulation of hair follicle developmentBiological ProcessIMP (16702408)
GO:0051092activation of NF-kappaB transcription factorBiological ProcessISS (15790681)
GO:0051023regulation of immunoglobulin secretionBiological ProcessIDA (12958312)
GO:0050900leukocyte migrationBiological ProcessIDA (15034066)
GO:0046330positive regulation of JNK cascadeBiological ProcessIGI (16260493)
GO:0046330positive regulation of JNK cascadeBiological ProcessIDA (16260493)
GO:0046325negative regulation of glucose importBiological ProcessIDA (12068289)
GO:0042127regulation of cell proliferationBiological ProcessIDA (11799106)
GO:0030316osteoclast differentiationBiological ProcessIGI (15485831)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (9305915)
GO:0006006glucose metabolic processBiological ProcessIDA (12068289)
GO:0006917induction of apoptosisBiological ProcessIDA (8208546)
GO:0006927transformed cell apoptosisBiological ProcessTAS (7636227|8171322|9368616)
GO:0006952defense responseBiological ProcessIMP (8395024|9223320)
GO:0006954inflammatory responseBiological ProcessTAS (8171322|8387893)
GO:0006955immune responseBiological ProcessIEA
GO:0006959humoral immune responseBiological ProcessIMP (8879212)
GO:0007275multicellular organismal developmentBiological ProcessIMP (9368616)
GO:0008283cell proliferationBiological ProcessTAS (7636227)
GO:0008284positive regulation of cell proliferationBiological ProcessTAS (8171322)
GO:0008624induction of apoptosis by extracellular signalsBiological ProcessIDA (15629131)
GO:0008625induction of apoptosis via death domain receptorsBiological ProcessIGI (12431371)
GO:0009887organ morphogenesisBiological ProcessIMP (8879212)
GO:0007254JNK cascadeBiological ProcessIGI (17015619)
GO:0001932regulation of protein amino acid phosphorylationBiological ProcessIDA (15169905)
Other Database Cross Links
NCBI Entrez Gene:21926
MGI:
Ensembl:ENSMUSG00000024401
dbSNP:Tnf
AceView:Tnf