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Gene Information
Gene ID:7124
Symbol:TNF
Full Name:tumor necrosis factor (TNF superfamily, member 2)
Alias:DIF|TNF-alpha|TNFA|TNFSF2
Organism:Homo sapiens (Human)
Chromosome:6
Genetic Location:6p21.3
Physical Location:31651328-31654090 on NC_000006.10
Gene Type:protein-coding
Orthologs:This gene has Mouse: 21926 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:TNF
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
TNF8Alcohol-Induced Disorders
TNF4Alcoholism
TNF8Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000594.2NP_000585.2NC_000006.10 range: 31651328..31654090
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentEXP (2848815|7758105|12887920)
GO:0005615extracellular spaceCellular ComponentIEA
GO:0005576extracellular regionCellular ComponentIEA
GO:0005125cytokine activityMolecular FunctionIEA
GO:0005164tumor necrosis factor receptor bindingMolecular FunctionIEA
GO:0042802identical protein bindingMolecular FunctionIDA (14512626)
GO:0033209tumor necrosis factor-mediated signaling pathwayBiological ProcessIMP (10748004)
GO:0042346positive regulation of NF-kappaB import into nucleusBiological ProcessIDA (17922812)
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeBiological ProcessIDA (17922812)
GO:0043193positive regulation of gene-specific transcriptionBiological ProcessIDA (14512626)
GO:0045071negative regulation of viral genome replicationBiological ProcessIDA (10490959)
GO:0045080positive regulation of chemokine biosynthetic processBiological ProcessIDA (10490959)
GO:0045941positive regulation of transcriptionBiological ProcessIDA (10748004)
GO:0051092activation of NF-kappaB transcription factorBiological ProcessIDA (16280327)
GO:0050901leukocyte tethering or rollingBiological ProcessIDA (10820279)
GO:0050715positive regulation of cytokine secretionBiological ProcessIDA (10443688)
GO:0048661positive regulation of smooth muscle cell proliferationBiological ProcessIDA (16518841)
GO:0032800receptor biosynthetic processBiological ProcessIDA (10443688)
GO:0032722positive regulation of chemokine productionBiological ProcessIDA (10490959)
GO:0032715negative regulation of interleukin-6 productionBiological ProcessIDA (10443688)
GO:0000187activation of MAPK activityBiological ProcessIDA (10748004)
GO:0001934positive regulation of protein amino acid phosphorylationBiological ProcessIDA (10748004)
GO:0002439chronic inflammatory response to antigenic stimulusBiological ProcessIMP (14512626)
GO:0002740negative regulation of cytokine secretion during immune responseBiological ProcessIDA (10443688)
GO:0006916anti-apoptosisBiological ProcessIDA (10748004)
GO:0006919caspase activationBiological ProcessIDA (14512626)
GO:0006927transformed cell apoptosisBiological ProcessIDA (3883195)
GO:0006954inflammatory responseBiological ProcessIDA (10748004)
GO:0006955immune responseBiological ProcessIEA
GO:0009615response to virusBiological ProcessIDA (10490959)
GO:0000060protein import into nucleus, translocationBiological ProcessIDA (16280327)
GO:0016481negative regulation of transcriptionBiological ProcessIDA (16895791)
GO:0051384response to glucocorticoid stimulusBiological ProcessIDA (10443688)
Other Database Cross Links
NCBI Entrez Gene:7124
HGNC:11892
Ensembl:ENSG00000204490
MIM:191160
HPRD:01855
HuGE Navigator:7124
dbSNP:TNF
GeneCard:TNF
AceView:TNF