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Gene Information
Gene ID:22059
Symbol:Trp53
Full Name:transformation related protein 53
Alias:bbl|bfy|bhy|p53
Organism:Mus musculus (Mouse)
Chromosome:11
Genetic Location:11 B2-C|11 39.0 cM
Physical Location:69393482-69405372 on NC_000077.5
Gene Type:protein-coding
Human Ortholog:GeneID: 7157    Symbol (Name): TP53 (tumor protein p53)
Ortholog Status:The human GeneID 7157 is also in human dataset(s).
Gene in Ethanol Study Datasets
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Lore4Alcohol-induced Loss of Righting Reflex11 36-42 (cM)6.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011640.3NP_035770.2NC_000077.5 range: 69393482..69405372
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentIDA (11799106)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISO
GO:0005737cytoplasmCellular ComponentIDA (11799106|11900485|12524542)
GO:0005657replication forkCellular ComponentIDA (15364958)
GO:0005634nucleusCellular ComponentISO
GO:0005634nucleusCellular ComponentIDA (11799106|11900485|12524542|14729462)
GO:0003700transcription factor activityMolecular FunctionIDA (12135983|16044147|16098148)
GO:0003677DNA bindingMolecular FunctionIDA (10205143|12135983|16107883|16363065)
GO:0003682chromatin bindingMolecular FunctionISO
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (10205143|10329696|10894779|11799106|11900485|15364958|15678128|15735665|15989966|16151013)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0042493response to drugBiological ProcessIDA (9098922)
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisBiological ProcessIGI (17476307)
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisBiological ProcessIMP (12952892|16777961)
GO:0030330DNA damage response, signal transduction by p53 class mediatorBiological ProcessIGI (16199867|17476307)
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisBiological ProcessISO
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisBiological ProcessISS (14654789)
GO:0042149cellular response to glucose starvationBiological ProcessISO
GO:0042127regulation of cell proliferationBiological ProcessIMP (12878730)
GO:0010332response to gamma radiationBiological ProcessIMP (17068116)
GO:0018144RNA-protein covalent cross-linkingBiological ProcessIEA
GO:0030308negative regulation of cell growthBiological ProcessIEA
GO:0030330DNA damage response, signal transduction by p53 class mediatorBiological ProcessIDA (11790307|11884608)
GO:0031571G1 DNA damage checkpointBiological ProcessIMP (16107883)
GO:0042981regulation of apoptosisBiological ProcessISO
GO:0043065positive regulation of apoptosisBiological ProcessIMP (17068116)
GO:0048147negative regulation of fibroblast proliferationBiological ProcessIMP (12952892)
GO:0048147negative regulation of fibroblast proliferationBiological ProcessIDA (17332504)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (8183579|16098148|16107883)
GO:0045941positive regulation of transcriptionBiological ProcessIGI (15735665)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISO
GO:0045941positive regulation of transcriptionBiological ProcessIDA (15735665)
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessIDA (16044147)
GO:0045786negative regulation of cell cycleBiological ProcessIEA
GO:0043525positive regulation of neuron apoptosisBiological ProcessIMP (9608530|11092819|15483136)
GO:0043525positive regulation of neuron apoptosisBiological ProcessIGI (10911993|16777961)
GO:0043525positive regulation of neuron apoptosisBiological ProcessIDA (10894779)
GO:0043523regulation of neuron apoptosisBiological ProcessIGI (15483136)
GO:0043066negative regulation of apoptosisBiological ProcessIMP (8183579|12952892|17912366)
GO:0051726regulation of cell cycleBiological ProcessIMP (15898111)
GO:0010332response to gamma radiationBiological ProcessIDA (14744935)
GO:0006917induction of apoptosisBiological ProcessIDA (16107883)
GO:0006915apoptosisBiological ProcessIGI (15485914)
GO:0006915apoptosisBiological ProcessIDA (16183742)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIDA (12135983)
GO:0006350transcriptionBiological ProcessIEA
GO:0006302double-strand break repairBiological ProcessIMP (17912366)
GO:0000060protein import into nucleus, translocationBiological ProcessIDA (11799106)
GO:0002360T cell lineage commitmentBiological ProcessIMP (8788039)
GO:0002347response to tumor cellBiological ProcessIEA
GO:0002326B cell lineage commitmentBiological ProcessIMP (8788039)
GO:0001836release of cytochrome c from mitochondriaBiological ProcessIDA (15483136)
GO:0001701in utero embryonic developmentBiological ProcessIGI (9425892)
GO:0001701in utero embryonic developmentBiological ProcessIGI (9288110)
GO:0006917induction of apoptosisBiological ProcessIMP (17210642)
GO:0006974response to DNA damage stimulusBiological ProcessIDA (14744935|15383658)
GO:0010165response to X-rayBiological ProcessIDA (11884608)
GO:0009792embryonic development ending in birth or egg hatchingBiological ProcessIGI (16702401)
GO:0009411response to UVBiological ProcessIMP (10815637|11092819|12952892)
GO:0009411response to UVBiological ProcessIDA (14744935)
GO:0008285negative regulation of cell proliferationBiological ProcessIGI (10591652|10591653|10973261|11246230)
GO:0008156negative regulation of DNA replicationBiological ProcessIMP (11884608)
GO:0008156negative regulation of DNA replicationBiological ProcessIDA (11884608)
GO:0007417central nervous system developmentBiological ProcessIGI (16199867)
GO:0007406negative regulation of neuroblast proliferationBiological ProcessIGI (9608530)
GO:0007049cell cycleBiological ProcessIEA
GO:0006983ER overload responseBiological ProcessISO
GO:0006974response to DNA damage stimulusBiological ProcessISO
GO:0006974response to DNA damage stimulusBiological ProcessIMP (11092819|12952892)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (8183579)
Other Database Cross Links
NCBI Entrez Gene:22059
MGI:
Ensembl:ENSMUSG00000059552
dbSNP:Trp53
AceView:Trp53