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Gene Information
Gene ID:7157
Symbol:TP53
Full Name:tumor protein p53
Alias:FLJ92943|LFS1|TRP53|p53
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17p13.1
Physical Location:7512444-7531641 on NC_000017.9, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 22059 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:TP53
Original ID2:X54156
Dataset Information
Name:11093800
Method:Microarray
Tissue:SH-SY5Y neuroblastoma cells
Phenotype:Ethanol response
Publication:Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.
Gene Information
Original ID1:TP53
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
TP531Alcoholism
TP531Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000546.4NP_000537.3NC_000017.9 range: 7512444..7531641, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005654nucleoplasmCellular ComponentIDA (11080164|12915590)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIDA (12667443)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIDA (7720704)
GO:0005730nucleolusCellular ComponentIDA (12080348)
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentIDA (7720704|16507995)
GO:0005626insoluble fractionCellular ComponentIDA (12915590)
GO:0016363nuclear matrixCellular ComponentIDA (11080164)
GO:0019899enzyme bindingMolecular FunctionIPI (10666337|15577914)
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIDA (8183576)
GO:0046982protein heterodimerization activityMolecular FunctionIPI (10837489)
GO:0047485protein N-terminus bindingMolecular FunctionIPI (11861836)
GO:0008270zinc ion bindingMolecular FunctionTAS (10065153)
GO:0004518nuclease activityMolecular FunctionTAS (11002423)
GO:0005507copper ion bindingMolecular FunctionIDA (7824276)
GO:0003682chromatin bindingMolecular FunctionIDA (17599062)
GO:0003700transcription factor activityMolecular FunctionIDA (7587074)
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0000739DNA strand annealing activityMolecular FunctionIDA (8183576)
GO:0005515protein bindingMolecular FunctionIPI (15782130)
GO:0030154cell differentiationBiological ProcessTAS (10065150)
GO:0051262protein tetramerizationBiological ProcessTAS (15116721)
GO:0018144RNA-protein covalent cross-linkingBiological ProcessIEA
GO:0030308negative regulation of cell growthBiological ProcessIMP (8986812)
GO:0042149cellular response to glucose starvationBiological ProcessIDA (14744935)
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisBiological ProcessIDA (14654789|14744935)
GO:0042981regulation of apoptosisBiological ProcessIDA (14744935)
GO:0045786negative regulation of cell cycleBiological ProcessIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (17599062)
GO:0051097negative regulation of helicase activityBiological ProcessTAS (7663514)
GO:0046902regulation of mitochondrial membrane permeabilityBiological ProcessTAS (15116721)
GO:0008635caspase activation via cytochrome cBiological ProcessIDA (12667443)
GO:0006284base-excision repairBiological ProcessTAS (15116721)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIDA (7587074)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006461protein complex assemblyBiological ProcessIDA (12915590)
GO:0006915apoptosisBiological ProcessIEA
GO:0006974response to DNA damage stimulusBiological ProcessIEP (8986812)
GO:0006983ER overload responseBiological ProcessIDA (14744935)
GO:0007050cell cycle arrestBiological ProcessTAS (8675009)
GO:0007275multicellular organismal developmentBiological ProcessIMP (10065150)
GO:0007569cell agingBiological ProcessIMP (12080348)
GO:0008104protein localizationBiological ProcessIDA (16507995)
GO:0006289nucleotide-excision repairBiological ProcessIMP (7663514)
GO:0008283cell proliferationBiological ProcessTAS (10065150)
GO:0008629induction of apoptosis by intracellular signalsBiological ProcessTAS (16462759)
GO:0002347response to tumor cellBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:7157
HGNC:11998
Ensembl:ENSG00000141510
MIM:191170
HPRD:01859
HuGE Navigator:7157
dbSNP:TP53
GeneCard:TP53
AceView:TP53