ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tbc1d22a

Full Name:

TBC1 domain family, member 22a

Alias:

BC023106|D15Ertd781e|MGC28337

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 E2|15 49.3 cM

Physical Location:

86044888-86328932 on NC_000081.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 25771 Symbol (Name): TBC1D22A (TBC1 domain family, member 22A)

Ortholog Status:

The human GeneID 25771 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15668661
Method:		Microarray
Tissue:		Fetal brain
Phenotype:		Ethanol response
Publication:		Hard et al. J Lab Clin Med. (2005) Gene-expression analysis after alcohol exposure in the developing mouse. PubMed
Summary:		Exposure to alcohol in the embryonic mouse can lead to structural and neurophysiologic changes. Here we investigate ethanol-induced alterations in gene expression in the fetal brain. Using complementary-DNA microarrays, we identified 25 genes that were down-regulated by prenatal ethanol exposure on days 7 and 9 of gestation. None were found to be up-regulated.

Gene Information

Original ID1:		D15Ertd781e
Original ID2:		AI849705

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_145476.2	NP_663451.2	NC_000081.5 range: 86044888..86328932

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005096	GTPase activator activity	Molecular Function	IEA
GO:0005097	Rab GTPase activator activity	Molecular Function	IEA
GO:0032313	regulation of Rab GTPase activity	Biological Process	IEA