ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FGF1

Full Name:

fibroblast growth factor 1 (acidic)

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q31

Physical Location:

141953305-142045811 on NC_000005.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X59065
Fold Change:		2.25

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Information

Original ID1:

FGF1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	EXP (1697263\|8622701\|9139660\|11294897\|16597617)
GO:0005576	extracellular region	Cellular Component	NR
GO:0005615	extracellular space	Cellular Component	NR
GO:0008201	heparin binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10618369\|14732692)
GO:0008083	growth factor activity	Molecular Function	TAS (1693186)
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0008283	cell proliferation	Biological Process	IEA
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	EXP (17133345)
GO:0009653	anatomical structure morphogenesis	Biological Process	TAS (1693186)
GO:0001525	angiogenesis	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	TAS (10903182)
GO:0007267	cell-cell signaling	Biological Process	NR
GO:0007165	signal transduction	Biological Process	NAS (3778488)
GO:0030154	cell differentiation	Biological Process	IEA