ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FGFR2

Full Name:

fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)

Alias:

BEK|BFR-1|CD332|CEK3|CFD1|ECT1|FLJ98662|JWS|JWS; TK14|K-SAM|KGFR|TK14|TK25

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10q26

Physical Location:

123227844-123347961 on NC_000010.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Z71929
Fold Change:		2.3

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000141.4	NP_000132.2	NC_000010.9 range: 123227844..123347961, complement
NM_022970.3	NP_075259.3	NC_000010.9 range: 123227844..123347961, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	NAS (1697263)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0009986	cell surface	Cellular Component	IEP (12493773)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	EXP (1697263\|11294897)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0008201	heparin binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10618369\|12591959\|17981115)
GO:0005007	fibroblast growth factor receptor activity	Molecular Function	NAS (1400433\|1697263\|8676562)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	NAS (1697263)
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	EXP (17133345)
GO:0016049	cell growth	Biological Process	NAS (8676562)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA