ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mark1

Full Name:

MAP/microtubule affinity-regulating kinase 1

Alias:

AW491150|B930025N23Rik|Emk3|KIAA1477|mKIAA1477

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H5

Physical Location:

186721481-186823357 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4139 Symbol (Name): MARK1 (MAP/microtubule affinity-regulating kinase 1)

Ortholog Status:

The human GeneID 4139 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mark1
Original ID2:		AA080253

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_145515.1	NP_663490.1	NC_000067.5 range: 186721481..186823357, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0016740	transferase activity	Molecular Function	RCA (12466851)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	RCA (12466851)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	RCA (12466851)
GO:0004672	protein kinase activity	Molecular Function	RCA (12466851)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	RCA (12466851)