ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gsn

Full Name:

gelsolin

Alias:

MGC28083

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 B|2 24.5 cM

Physical Location:

35137959-35163411 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2934 Symbol (Name): GSN (gelsolin (amyloidosis, Finnish type))

Ortholog Status:

The human GeneID 2934 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gsn
Fold Change:		0.57
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcp1	Alcohol Preference Drinking	2	28	19-35 (cM)	5.3		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_146120.3	NP_666232.2	NC_000068.6 range: 35137959..35163411

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0030027	lamellipodium	Cellular Component	IDA (15294161)
GO:0015629	actin cytoskeleton	Cellular Component	RCA (12466851)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005737	cytoplasm	Cellular Component	RCA (12466851)
GO:0003779	actin binding	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	RCA (12466851)
GO:0005198	structural molecule activity	Molecular Function	RCA (12466851)
GO:0016192	vesicle-mediated transport	Biological Process	IMP (11514591)
GO:0051014	actin filament severing	Biological Process	RCA (12466851)
GO:0051016	barbed-end actin filament capping	Biological Process	RCA (12466851)