ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GSN

Full Name:

gelsolin (amyloidosis, Finnish type)

Alias:

DKFZp313L0718

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9q33

Physical Location:

123070200-123134940 on NC_000009.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 227753 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D9S934

2.28

0.0006

120135477

D9S1682

2.33

0.0005

124033322

Region:		120135477-124033322
Phenotype:		ONSET (age at onset of AD)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0015629	actin cytoskeleton	Cellular Component	TAS (1321812)
GO:0005829	cytosol	Cellular Component	IDA (3020431)
GO:0005576	extracellular region	Cellular Component	IDA (3020431)
GO:0005576	extracellular region	Cellular Component	NAS (14718574)
GO:0003779	actin binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10793131\|12732734\|17353931\|17373842)
GO:0005509	calcium ion binding	Molecular Function	TAS (1321812)
GO:0030041	actin filament polymerization	Biological Process	IDA (3020431)
GO:0051014	actin filament severing	Biological Process	IDA (3020431)
GO:0051016	barbed-end actin filament capping	Biological Process	TAS (1321812)