ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

COPZ1

Full Name:

coatomer protein complex, subunit zeta 1

Alias:

CGI-120|COPZ|zeta1-COP

Organism:

Homo sapiens (Human)

Chromosome:

12

Genetic Location:

12q13.2-q13.3

Physical Location:

53005177-53031899 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.505652
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016057.1	NP_057141.1	NC_000012.10 range: 53005177..53031899

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0030117	membrane coat	Cellular Component	IEA
GO:0030126	COPI vesicle coat	Cellular Component	IDA (11056392)
GO:0030126	COPI vesicle coat	Cellular Component	ISS
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (8533093\|8599108)
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0016192	vesicle-mediated transport	Biological Process	IEA
GO:0016044	membrane organization and biogenesis	Biological Process	EXP (11031247)
GO:0006891	intra-Golgi vesicle-mediated transport	Biological Process	ISS
GO:0006891	intra-Golgi vesicle-mediated transport	Biological Process	IDA (11056392)
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	Biological Process	TAS (11030615)
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	Biological Process	EXP (11031247)
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0048205	COPI coating of Golgi vesicle	Biological Process	EXP (16956762)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000111481

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: