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Gene Information
Gene ID:232223
Full Name:thioredoxin reductase 3
Organism:Mus musculus (Mouse)
Genetic Location:6 D1
Physical Location:89593981-89625522 on NC_000072.5
Gene Type:protein-coding
Human Ortholog:GeneID: 114112    Symbol (Name): TXNRD3 (thioredoxin reductase 3)
Ortholog Status:The human GeneID 114112 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Txnrd3
Original ID2:AV299386
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_153162.3NP_694802.2NC_000072.5 range: 89593981..89625522
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentRCA (16141072)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005792microsomeCellular ComponentIDA (11259642)
GO:0004791thioredoxin-disulfide reductase activityMolecular FunctionIDA (11259642)
GO:0015035protein disulfide oxidoreductase activityMolecular FunctionIEA
GO:0015036disulfide oxidoreductase activityMolecular FunctionRCA (16141072)
GO:0016491oxidoreductase activityMolecular FunctionRCA (16141072)
GO:0016654oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptorMolecular FunctionRCA (16141072)
GO:0050660FAD bindingMolecular FunctionIEA
GO:0009055electron carrier activityMolecular FunctionRCA (16141072)
GO:0008483transaminase activityMolecular FunctionRCA (16141072)
GO:0050661NADP bindingMolecular FunctionIEA
GO:0008430selenium bindingMolecular FunctionIEA
GO:0007283spermatogenesisBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0009058biosynthetic processBiological ProcessRCA (16141072)
GO:0030154cell differentiationBiological ProcessIEA
GO:0045454cell redox homeostasisBiological ProcessIEA
GO:0006749glutathione metabolic processBiological ProcessIDA (11259642)
GO:0006810transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:232223