ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Txnrd3

Full Name:

thioredoxin reductase 3

Alias:

AI196535|TR2|Tgr

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 D1

Physical Location:

89593981-89625522 on NC_000072.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 114112 Symbol (Name): TXNRD3 (thioredoxin reductase 3)

Ortholog Status:

The human GeneID 114112 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Txnrd3
Original ID2:		AV299386

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_153162.3	NP_694802.2	NC_000072.5 range: 89593981..89625522

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	RCA (16141072)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005792	microsome	Cellular Component	IDA (11259642)
GO:0004791	thioredoxin-disulfide reductase activity	Molecular Function	IDA (11259642)
GO:0015035	protein disulfide oxidoreductase activity	Molecular Function	IEA
GO:0015036	disulfide oxidoreductase activity	Molecular Function	RCA (16141072)
GO:0016491	oxidoreductase activity	Molecular Function	RCA (16141072)
GO:0016654	oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor	Molecular Function	RCA (16141072)
GO:0050660	FAD binding	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	RCA (16141072)
GO:0008483	transaminase activity	Molecular Function	RCA (16141072)
GO:0050661	NADP binding	Molecular Function	IEA
GO:0008430	selenium binding	Molecular Function	IEA
GO:0007283	spermatogenesis	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0009058	biosynthetic process	Biological Process	RCA (16141072)
GO:0030154	cell differentiation	Biological Process	IEA
GO:0045454	cell redox homeostasis	Biological Process	IEA
GO:0006749	glutathione metabolic process	Biological Process	IDA (11259642)
GO:0006810	transport	Biological Process	IEA