ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ATP11A

Full Name:

ATPase, class VI, type 11A

Alias:

ATPIH|ATPIS

Organism:

Homo sapiens (Human)

Chromosome:

13

Genetic Location:

13q34

Physical Location:

112392643-112589482 on NC_000013.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.29189
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_015205.2	NP_056020.2	NC_000013.9 range: 112392643..112589482
NM_032189.3	NP_115565.3	NC_000013.9 range: 112392643..112589482

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004012	phospholipid-translocating ATPase activity	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0015914	phospholipid transport	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000068650

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: