ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Zbtb45

Full Name:

zinc finger and BTB domain containing 45

Alias:

BB161562|Gm157|MGC106784|Zfp499

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

7 A1

Physical Location:

13591014-13595148 on NC_000073.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 84878 Symbol (Name): ZBTB45 (zinc finger and BTB domain containing 45)

Ortholog Status:

The human GeneID 84878 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI595382
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Information

Original ID1:

Gm157

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001024699.1	NP_001019870.1	NC_000073.5 range: 13591014..13595148, complement

Gene Ontology (GO) Annotation