ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

KIF13B

Full Name:

kinesin family member 13B

Alias:

GAKIN|KIAA0639

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8p21.1

Physical Location:

28980713-29176528 on NC_000008.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.444767
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene SNP Information

SNP	Abuser/Control Ratio	Cluster
rs524458 dbSNP	1.19	34

Association Dataset

Name:		16894614
Method:		Association
Publication:		Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Summary:		Association genome scanning can identify markers for the allelic variants that contribute to vulnerability to complex disorders, including alcohol dependence. To improve the power and feasibility of this approach, we report validation of 100k microarray-based allelic frequency assessments in pooled DNA samples. We then use this approach with unrelated alcohol-dependent versus control individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA). Allele frequency differences between alcohol-dependent and control individuals are assessed in quadruplicate at 104,268 autosomal SNPs in pooled samples. One hundred eighty-eight SNPs provide (1) the largest allele frequency differences between dependent versus control individuals; (2) t values 3 for these differences; and (3) clustering, so that 51 relatively small chromosomal regions contain at least three SNPs that satisfy criteria 1 and 2 above (Monte Carlo P = 0.00034).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_015254.3	NP_056069.2	NC_000008.9 range: 28980713..29176528, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005874	microtubule	Cellular Component	IEA
GO:0005875	microtubule associated complex	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IDA (10859302)
GO:0019901	protein kinase binding	Molecular Function	IPI (10859302)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10859302)
GO:0003777	microtubule motor activity	Molecular Function	NAS (10859302)
GO:0003777	microtubule motor activity	Molecular Function	IEA
GO:0006605	protein targeting	Biological Process	TAS (10859302)
GO:0007018	microtubule-based movement	Biological Process	IEA
GO:0007018	microtubule-based movement	Biological Process	TAS (10859302)
GO:0007165	signal transduction	Biological Process	NAS (10859302)
GO:0042110	T cell activation	Biological Process	NAS (12496241)