ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

DICER1

Full Name:

dicer 1, ribonuclease type III

Alias:

DCR1|Dicer|HERNA|KIAA0928

Organism:

Homo sapiens (Human)

Chromosome:

14

Genetic Location:

14q32.13

Physical Location:

94622318-94693511 on NC_000014.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.87889
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_030621.3	NP_085124.2	NC_000014.7 range: 94622318..94693511, complement
NM_177438.2	NP_803187.1	NC_000014.7 range: 94622318..94693511, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	NAS (12560494)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008026	ATP-dependent helicase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12526743\|14749716\|16142218)
GO:0004525	ribonuclease III activity	Molecular Function	IDA (12560494)
GO:0004519	endonuclease activity	Molecular Function	IEA
GO:0003725	double-stranded RNA binding	Molecular Function	IDA (12411504)
GO:0006396	RNA processing	Biological Process	IEA
GO:0030423	RNA interference, targeting of mRNA for destruction	Biological Process	IEP (12560494)
GO:0031047	gene silencing by RNA	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000100697

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: