ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SIRT1

Full Name:

sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

Alias:

SIR2L1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10q21.3

Physical Location:

69314432-69348148 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 34708 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

SIRT1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012238.3	NP_036370.2	NC_000010.9 range: 69314432..69348148

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005677	chromatin silencing complex	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0017136	NAD-dependent histone deacetylase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0051287	NAD binding	Molecular Function	IEA
GO:0003950	NAD+ ADP-ribosyltransferase activity	Molecular Function	TAS (10381378)
GO:0006476	protein amino acid deacetylation	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0006342	chromatin silencing	Biological Process	TAS (10381378)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0007519	skeletal muscle development	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0006471	protein amino acid ADP-ribosylation	Biological Process	TAS (10381378)
GO:0006915	apoptosis	Biological Process	IEA