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Gene Information
Gene ID:23411
Symbol:SIRT1
Full Name:sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
Alias:SIR2L1
Organism:Homo sapiens (Human)
Chromosome:10
Genetic Location:10q21.3
Physical Location:69314432-69348148 on NC_000010.9
Gene Type:protein-coding
Orthologs:This gene has Fly: 34708 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:SIRT1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012238.3NP_036370.2NC_000010.9 range: 69314432..69348148
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005677chromatin silencing complexCellular ComponentIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0017136NAD-dependent histone deacetylase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0051287NAD bindingMolecular FunctionIEA
GO:0003950NAD+ ADP-ribosyltransferase activityMolecular FunctionTAS (10381378)
GO:0006476protein amino acid deacetylationBiological ProcessIEA
GO:0030154cell differentiationBiological ProcessIEA
GO:0006342chromatin silencingBiological ProcessTAS (10381378)
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0007519skeletal muscle developmentBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0006471protein amino acid ADP-ribosylationBiological ProcessTAS (10381378)
GO:0006915apoptosisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:23411
HGNC:14929
Ensembl:ENSG00000096717
MIM:604479
HPRD:08381
HuGE Navigator:23411
dbSNP:SIRT1
GeneCard:SIRT1
AceView:SIRT1