ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sir2

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

34A7-34A7

Physical Location:

13165550-13169550 on NT_033779.4

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23411 Symbol (Name): SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))

Ortholog Status:

The human GeneID 23411 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_058003.3	NP_477351.1	NT_033779.4 range: 13165550..13169550

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12524341)
GO:0005654	nucleoplasm	Cellular Component	IDA (16219773)
GO:0005677	chromatin silencing complex	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IDA (12524341)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0017136	NAD-dependent histone deacetylase activity	Molecular Function	ISS
GO:0017136	NAD-dependent histone deacetylase activity	Molecular Function	IDA (11812793\|12086602\|12524341\|15498488)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0051287	NAD binding	Molecular Function	IEA
GO:0004407	histone deacetylase activity	Molecular Function	IDA (11281647\|16137856)
GO:0008340	determination of adult life span	Biological Process	IMP
GO:0016575	histone deacetylation	Biological Process	IDA (11812793)
GO:0006342	chromatin silencing	Biological Process	IMP (16219773)
GO:0035065	regulation of histone acetylation	Biological Process	IMP (16219773)
GO:0007584	response to nutrient	Biological Process	IMP