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Gene Information
Gene ID:235320
Symbol:Zbtb16
Full Name:zinc finger and BTB domain containing 16
Alias:AI467657|PLZF|Zfp145|lu
Organism:Mus musculus (Mouse)
Chromosome:9
Genetic Location:9 A5.3|9 23.0 cM
Physical Location:48462401-48644049 on NC_000075.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7704    Symbol (Name): ZBTB16 (zinc finger and BTB domain containing 16)
Ortholog Status:The human GeneID 7704 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Zfp145
Original ID2:AI553024
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Ap5qAlcohol Preference Drinking92510-35 (cM)4.8 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001033324.2NP_001028496.1NC_000075.5 range: 48462401..48644049, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016607nuclear speckCellular ComponentISS (8541544)
GO:0017053transcriptional repressor complexCellular ComponentISO
GO:0005634nucleusCellular ComponentISO
GO:0005634nucleusCellular ComponentIDA (15156142|16564520)
GO:0016566specific transcriptional repressor activityMolecular FunctionISO
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISO
GO:0005515protein bindingMolecular FunctionIPI (10207085|15528197)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionISO
GO:0035116embryonic hindlimb morphogenesisBiological ProcessIMP (10835630)
GO:0035136forelimb morphogenesisBiological ProcessIMP (10835630)
GO:0043065positive regulation of apoptosisBiological ProcessIMP (10835630)
GO:0045449regulation of transcriptionBiological ProcessIMP (10835630)
GO:0045638negative regulation of myeloid cell differentiationBiological ProcessIDA (8541544)
GO:0045892negative regulation of transcription, DNA-dependentBiological ProcessISO
GO:0035110leg morphogenesisBiological ProcessIMP (10835630)
GO:0030326embryonic limb morphogenesisBiological ProcessIMP
GO:0030097hemopoiesisBiological ProcessIDA (8541544)
GO:0001501skeletal developmentBiological ProcessIMP (6068186|10835630)
GO:0009952anterior/posterior pattern formationBiological ProcessIMP (10835630)
GO:0009880embryonic pattern specificationBiological ProcessIMP (10835630)
GO:0008285negative regulation of cell proliferationBiological ProcessIMP (10835630)
GO:0007417central nervous system developmentBiological ProcessIDA (8541544)
GO:0001823mesonephros developmentBiological ProcessIDA (8541544)
GO:0048133male germ-line stem cell divisionBiological ProcessIMP (15156142|15156143)
Other Database Cross Links
NCBI Entrez Gene:235320
MGI:
Ensembl:ENSMUSG00000066687
dbSNP:Zbtb16
AceView:Zbtb16