| Gene Information |
| Gene ID: | | 2355 |
| Symbol: | | FOSL2 |
| Full Name: | | FOS-like antigen 2 |
| Alias: | | FLJ23306|FRA2 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 2 |
| Genetic Location: | | 2p23.3 |
| Physical Location: | | 28469282-28491019 on NC_000002.10 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
|
| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | 18477577 | | Method: | | Addiction array gene list | | Publication: | | Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed | | Summary: | | To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior. |
|
|
| Gene Refseq Sequence Annotation |
|
| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005634 | nucleus | Cellular Component | TAS (8954781) | |
| GO:0003700 | transcription factor activity | Molecular Function | TAS (8954781) | |
| GO:0043565 | sequence-specific DNA binding | Molecular Function | IEA | |
| GO:0046983 | protein dimerization activity | Molecular Function | IEA | |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | Biological Process | TAS (8954781) | |
| GO:0008219 | cell death | Biological Process | TAS (8954781) | |
|
| Other Database Cross Links |
| NCBI Entrez Gene: | | 2355 |
| HGNC: | | 3798 |
| Ensembl: | | ENSG00000075426 |
| MIM: | | 601575 |
| HPRD: | | 03343 |
| HuGE Navigator: | | 2355 |
| dbSNP: | | FOSL2 |
| GeneCard: | | FOSL2 |
| AceView: | | FOSL2 |
