ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nek4

Full Name:

NIMA (never in mitosis gene a)-related expressed kinase 4

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

14 B

Physical Location:

31764673-31800586 on NC_000080.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6787 Symbol (Name): NEK4 (NIMA (never in mitosis gene a)-related kinase 4)

Ortholog Status:

The human GeneID 6787 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AJ223071
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011849.2	NP_035979.1	NC_000080.5 range: 31764673..31800586

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	RCA (16141072)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0007067	mitosis	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	RCA (16141072)
GO:0051301	cell division	Biological Process	IEA