ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

A2m

Full Name:

alpha-2-macroglobulin

Alias:

A2MAC1|A2m1|A2maa|MGC114358|Mam|RATA2MAC1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q42

Physical Location:

158103688-158153421 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2 Symbol (Name): A2M (alpha-2-macroglobulin)

Ortholog Status:

The human GeneID 2 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		A2m
Fold Change:		-1.23
P Value:		0.008
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012488.2	NP_036620.2	NC_005103.2 range: 158103688..158153421

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0004867	serine-type endopeptidase inhibitor activity	Molecular Function	IEA
GO:0019959	interleukin-8 binding	Molecular Function	IEA
GO:0019959	interleukin-8 binding	Molecular Function	ISS
GO:0019966	interleukin-1 binding	Molecular Function	IEA
GO:0019966	interleukin-1 binding	Molecular Function	ISS
GO:0030414	protease inhibitor activity	Molecular Function	TAS (2581948)
GO:0043120	tumor necrosis factor binding	Molecular Function	IEA
GO:0043120	tumor necrosis factor binding	Molecular Function	ISS
GO:0019899	enzyme binding	Molecular Function	ISS
GO:0019899	enzyme binding	Molecular Function	IEA
GO:0017114	wide-spectrum protease inhibitor activity	Molecular Function	IEA
GO:0005102	receptor binding	Molecular Function	TAS (11839752)
GO:0006953	acute-phase response	Biological Process	IEA
GO:0042221	response to chemical stimulus	Biological Process	IEP (12221929)
GO:0006953	acute-phase response	Biological Process	IEP (2468362)
GO:0006954	inflammatory response	Biological Process	TAS (2581948)
GO:0007584	response to nutrient	Biological Process	IEP (9446838)
GO:0009611	response to wounding	Biological Process	TAS (2468362)
GO:0010037	response to carbon dioxide	Biological Process	IEP (12042906)
GO:0051384	response to glucocorticoid stimulus	Biological Process	IEP (2436819)