| Gene Information |
| Gene ID: | | 24159 |
| Symbol: | | Acly |
| Full Name: | | ATP citrate lyase |
| Alias: | | ACL|Clatp|MGC124629 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 10 |
| Genetic Location: | | 10q32.1 |
| Physical Location: | | 89420940-89471348 on NC_005109.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 47 Symbol (Name): ACLY (ATP citrate lyase) |
| Ortholog Status: | | The human GeneID 47 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Acly | | Fold Change: | | 1.16 | | P Value: | | 0.005 | | Note: | | Differential expression between ethanol and water groups in amygdala |
| | Gene Information | | Original ID1: | | Acly | | Fold Change: | | 1.14 | | P Value: | | 0.008 | | Note: | | Differential expression between ethanol and saccharin groups in amygdala |
| | Dataset Information | | Name: | | 18405950 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens and amygdala | | Phenotype: | | Ethanol self-administration, alcohol-preferring | | Publication: | | Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed | | Summary: | | The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0003878 | ATP citrate synthase activity | Molecular Function | IDA (2295639) | |
| GO:0005488 | binding | Molecular Function | IEA | |
| GO:0005515 | protein binding | Molecular Function | ISS | |
| GO:0016829 | lyase activity | Molecular Function | IEA | |
| GO:0006085 | acetyl-CoA biosynthetic process | Biological Process | NAS (2295639) | |
| GO:0006629 | lipid metabolic process | Biological Process | IEP (2295639) | |
| GO:0008152 | metabolic process | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 24159 |
| RGD: | | 2018 |
| Ensembl: | | ENSRNOG00000016924 |
| dbSNP: | | Acly |
